TAM Receptor
Tyro3; Axl; Mer
TAM receptors, comprising of Tyro3, Axl and Mertk receptors, are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells. The TAM family of receptors and their ligands Gas6 and Protein S (PROS1) are required for the optimal phagocytosis of apoptotic cells in the mature immune, nervous, and reproductive systems.
TAMs are three homologous type I receptor-tyrosine kinases that are activated by endogenous ligands, PROS1 and GAS6. These ligands can either activate TAMs as soluble factors, or, in turn, opsonize phosphatidylserine (PS) on apoptotic cells (ACs) and serve as bridging molecules between ACs and TAMs. Abnormal expression and activation of TAMs have been implicated in promoting proliferation and survival of cancer cells, as well as in suppressing anti-tumor immunity.
TAM Receptor Isoform Specific Products
All Product Categories
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TAM Receptor Related Products (107)
Related Products (107)
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Recombinant Proteins (34)
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Antibodies (2)
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TAM Receptor Isoform Comparison
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Ningetinib Tosylate (Standard)
0 ImagesCat. No.: HY-107145RCAS No.: 1394820-77-9Ningetinib Tosylate (Standard) is the analytical standard of Ningetinib Tosylate (HY-107145). This product is intended for research and analytical applications. Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine Kinase inhibitor (TKi) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
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SLC-391
0 ImagesCat. No.: HY-177332CAS No.: 1783825-18-2SLC-391 is an orally active AXL kinase inhibitor with an IC50 of 9.6 nM against AXL kinase. SLC-391 inhibits Gas6-induced AXL-dependent phosphorylation of Akt. SLC-391 inhibits SARS-CoV-2 infection, entry and replication in cells. SLC-391 suppresses cancer cell proliferation. SLC-391 inhibits tumor growth in mouse solid tumor xenograft models. SLC-391 can be used for the research of COVID-19, influenza virus infection, triple-negative breast cancer, chronic myeloid leukemia and non-small cell lung cancer.
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CEP-40783 (Standard)
0 ImagesCat. No.: HY-100946RCAS No.: 1437321-24-8Synonyms: RXDX-106 (Standard)
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Ningetinib (Standard)
0 ImagesCat. No.: HY-107145ARCAS No.: 1394820-69-9Ningetinib (Standard) is the analytical standard of Ningetinib (HY-107145A). This product is intended for research and analytical applications. Ningetinib is a potent, orally bioavailable small molecule tyrosine Kinase inhibitor (TKi) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
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Gilteritinib hemifumarate (Standard)
0 ImagesSynonyms: ASP2215 hemifumarate (Standard)Gilteritinib hemifumarate (Standard) is the analytical standard of Gilteritinib hemifumarate. This product is intended for research and analytical applications. Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.
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ER-851
0 ImagesCat. No.: HY-164382CAS No.: 2685738-33-2ER-851 is a selective AXL inhibitor with oral activity with IC50 of 100 nM. ER-851 has antitumor activity.
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NPS-1034 (Standard)
0 ImagesCat. No.: HY-100509RCAS No.: 1221713-92-3
